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To clarify the role of adrenal sex steroids and their derivatives on bone reso rption in oophorectomized women. Cross-sectional study. Department of Obstetric s and Gynecology, Graduate School of Medical Sciences, Kyushu University. Forty -eight women who were within one year of bilateral oophorectomy were recruited for this study. None of the subjects were treated with the drugs affecting bone metabolism. Urinary deoxypyridinoline (Dpyr) as marker of bone resorption and se rum DHEAS, androstenedione (A-dione), testosterone (T) and estrone (E1) levels as adrenal sex steroids and their derivatives. There was an inverse correlation between urinary Dpyr and serum concentrations of E1,DHEAS, or A-dione. There wa s no significant relationship between urinary Dpyr and T. These results suggest that adrenal steroids and their derivatives may influence the bone resorption in oophorectomized women.
To clarify the role of adrenal sex steroids and their derivatives on bone reso rption in oophorectomized women. Cross-sectional study. Department of Obstetric s and Gynecology, Graduate School of Medical Sciences, Kyushu University. Forty -eight women who were within one year of None of the subjects were treated with the drugs affect bone metabolism. Urinary deoxypyridinoline (Dpyr) as marker of bone resorption and se rum DHEAS, androstenedione (A-dione), testosterone (T) and estrone E1) levels as adrenal sex steroids and their derivatives. There was an inverse correlation between urinary Dpyr and serum concentrations of E1, DHEAS, or A-dione. There wa no significant relationship between urinary Dpyr and T. These results suggest that adrenal steroids and their derivatives may influence the bone resorption in oophorectomized women.