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研究了苯甲酰化壳聚糖(DBC)和天然生物分子氨基酸在选择性溶剂N,N-二甲苯甲酰胺(DMF)和水中的自组装行为.在超声波作用下,透明的混合溶液出现蓝白色乳光,同时紫外-可见光谱呈现透光率的突变,体系完成了自组装.自组装是通过两组分之间的氢键作用产生的.用动态光散射(DLS)和透射电镜(TEM)分别研究了自组装粒子的尺寸和形态.实验结果表明,苯甲酰化壳聚糖和氨基酸可以形成纳米尺寸或亚微米尺寸的自组装微粒,形成的微粒为球形或椭球形,微粒的尺寸为60~720 nm.粒子的尺寸显著受pH值和氨基酸种类的影响,因而可以利用pH值和氨基酸的种类控制自组装粒子的尺寸.
The self-assembly behaviors of benzamidated chitosan (DBC) and natural biomolecule amino acids in N, N-dimethylformamide (DMF) and water were investigated. Under ultrasonic irradiation, White opalescence, at the same time, the UV-visible spectrum showed the change of light transmittance, and the system completed the self-assembly.The self-assembly was produced by the hydrogen bonding between the two components.Using dynamic light scattering (DLS) and transmission electron microscopy ) Were studied the size and morphology of the self-assembled particles.The experimental results show that benzoylated chitosan and amino acids can form nano-sized or submicron size self-assembled particles, the formation of the particles are spherical or ellipsoidal, the size of the particles Is from 60 to 720 nm The size of the particles is significantly affected by the pH value and the type of amino acids so that the size of the self-assembled particles can be controlled by the pH and amino acid species.