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The mechanisms of action on monofunctional guanine adducts of analogues of transplatin with aliphatic amine ligands,such as trans-[Pt(Am)(isopropylamine)(G)(H2O)] where Am represents dimethylamine,propylamine or isopropylamine and their cis isomers reacting with sulfur- and nitrogen-containing amino acid residues,were explored. Histidine and lysine residues are chosen as the model ligands of nitrogen-containing amino acid residues of proteins; meanwhile,methionine and cysteine residues are chosen as the model ligands of sulfur-containing amino acid residues of proteins. A dominating preference for sulfur-containing ligand over nitrogen-containing ligand is established. The calculated smallest activation barrier for sulfur-containing ligand is 9.9,and 21.1 kcal/mol for nitrogen-containing ligand in aqueous solution,and both of them have trans configurations. The difference in activation energy is 11.2 kcal/mol,indicating the platination of sulfur-containing amino acid residues is faster by seven to eight orders of magnitude than that of nitrogen-containing amino acid residues.
The mechanisms of action on monofunctional guanine adducts of analogues of transplatin with an aliphatic amine ligands, such as trans- [Pt (Am) (isopropylamine) (G) (H2O)] where Am represents dimethylamine, propylamine or isopropylamine and their cis isomers reacting with sulfur- and nitrogen-containing amino acid residues, were explored. Histidine and lysine residues are chosen as the model ligands of nitrogen-containing amino acid residues of proteins; meanwhile, methionine and cysteine residues are chosen as the model ligands of sulfur-containing amino The lesser activation barrier for sulfur-containing ligands is 9.9 and 21.1 kcal / mol for nitrogen-containing ligands in aqueous solution, and both of them have trans configurations. The difference in activation energy is 11.2 kcal / mol, indicating the platination of sulfur-containing amino acid residues is faster by seven to eight orders of magnitude than that of nitrogen-containing amino acid residues.