早在1944年青霉素发现时期,人们就发现了抗生素后效应(Post-antibiotic effoct,PAE)现象。PAE系指细菌和抗生素短暂接触,当抗菌药物被清除后,细菌生长仍然受到持续抑制的效应。目前PAE已成为评价抗菌药物药效学的指标和临床制定给药方案的重要依据。本文对β—内酰胺类抗菌药物的PAE产生机制、体内外监测方法、影响因素、临床意义综述如下。 As early as the 1944 penicillin discovery period, people discovered the post-antibiotic effoct (PAE) phenomenon. PAE refers to brief contact between bacteria and antibiotics, and when the antibacterial is cleared, bacterial growth continues to be inhibited. At present, PAE has become an important index for evaluating the pharmacodynamics of antimicrobial agents and the clinical formulation of drug delivery plans. In this paper, the mechanism of PAE production of β-lactam antibiotics, in vitro and in vivo monitoring methods, influencing factors and clinical significance are summarized as follows.