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本研究测定了心血管疾病等的β-烯醇酶(β-enolase,β-Eno),以确定该酶能否用作急性心肌梗塞(AMI)的诊断指标。研究对象是首发 AMI 而无神经肌肉疾病患者26例,年龄38～84,男21,女5例。心绞痛10例,非 AMI所致充血性心力衰竭8例,特发性心肌病3例。心源性休克和应用强心药者除外。并研究20名健康人,年龄20～70,男15,女5名;10例肾功能衰竭(肾衰)或肝病患者。结果 20名健康人β-Eno 为5.6±3.1ng/ml。AMI 患者系列血清标本的β-Eno 峰值显著升高(高于正常值4～22倍)。急性心绞痛发作后12～14h 达到峰值浓度,持续1h 以上,然后渐恢复至正常。轻病组13例的β-Eno 升高出现在肌酸激酶(CK)
This study determined beta-enolase (beta-enolase), such as cardiovascular disease, to determine whether this enzyme could be used as a diagnostic marker for acute myocardial infarction (AMI). The subjects were 26 patients with AMI without neuromuscular disease, ranging in age from 38 to 84, males 21 and females. 10 cases of angina pectoris, 8 cases of congestive heart failure caused by non AMI and 3 cases of idiopathic cardiomyopathy. Cardiac shock and cardiac specialists are excluded. And study 20 healthy people, age 20 ~ 70, male 15, female 5; 10 cases of renal failure (renal failure) or liver disease. Results The β-Eno of 20 healthy people was 5.6 ± 3.1ng / ml. Serum samples of AMI patients had significantly higher β-Eno peak (4 to 22 times higher than normal). After the onset of acute angina 12 to 14h peak concentration, lasting more than 1h, then gradually returned to normal. 13 cases of mild disease group increased β-Eno appear in creatine kinase (CK)