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New tetraazamacrocyclic ligand with 1,4,7,10 tetrakis(4 nitrobenzyl) pendent groups (C 36 H 40 N 8O 8, M r =712.76) crystallized in the monoclinic system, P2 1/n space group with unit cell parameters: a=7.834(2), b=22.902(6), c=10^147(3), β=106.53(2)°, V=1745(1) 3, Z=2, D c =1.356 g/cm 3, λ (Mo Kα )=0.71069; μ =0.92cm -1 , F(000)=752, T =296K. The final R and R w values are 0^065 and 0.066, respectively. The Cu(Ⅱ), Ni(Ⅱ), Co(Ⅱ), Zn(Ⅱ) complexes with this new ligand have been synthesized and characterized by elemental analyses, IR, UV, ESI MS and molar conductance. The macrocyclic ligand molecular structure is centrosymmetrical. All complexes are in accordance with the general formula: M(L)(NO 3) 2·nH 2O (M=Co, Ni, Cu, n=2; M=Zn, n=4; L=C 36 H 40 |N 8O 8). The central metal ions coordinate to four nitrogen atoms of azamacrocycle and two oxygen atoms of one nitrate ion. Preliminary pharmacological tests against P 388 and A 549 tumor cell lines showed that all these complexes had considerable activities in vitro.
New tetraazamacrocyclic ligand with 1,4,7,10 tetrakis (4 nitrobenzyl) pendent groups (C 36 H 40 N 8O 8, M r = 712.76) crystallized in the monoclinic system, P2 1 / n space group with unit cell parameters: a = 7.834 (2), b = 22.902 (6), c = 10 ^ 147 (3) , β = 106.53 (2) °, V = 1745 1 3, Z = 2, D c = 1.356 The final R and R w values are 0 ^ 065 and 0.066, respectively. The final R and R w values are given by the following formula: g / cm 3, λ (Mo Kα) = 0.71069; μ = 0.92cm -1, F (000) = 752, T = 296K. The Cu (II), Ni (II), Co (II), Zn (II) complexes with this new ligand have been synthesized and characterized by elemental analyzes, IR, UV, ESI MS and molar conductance. The macrocyclic ligand molecular structure is All complexes are in accordance with the general formula: M (L) (NO 3) 2 · nH 2O (M = Co, Ni, Cu, n = 2; M = Zn, n = 4; L = C 36 H 40 | | N 8O 8). The central metal ions coordinate to four nitrogen atoms of azamacrocycle and two oxygen atoms of one nitrate ion. Preliminary pharmacolog ical tests against P 388 and A 549 tumor cell lines showed that all of these complexes had considerable activities in vitro.