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目的 观察冠心病 (CAD)合并糖尿病 (DM)患者冠状动脉介入术前后血栓形成前状态(PTS)分子标志物变化情况。方法 选择 32例CAD(A组 )及 2 4例CAD合并非胰岛素依赖性糖尿病(NIDDM ,B组 )患者行冠状动脉介入术 ,分别在术前、术后 2 0min、2 4h、7d采血测定PTS分子标志物、脂质过氧化物 (LPO)及血管内皮功能指标。结果 术后两组患者PTS分子标志物、LPO及内皮功能均较术前有明显变化 ,且B组变化更明显 ,至术后第 7d ,A组基本恢复至术前水平 ,但B组仍有明显变化。结论 CAD患者介入术后出现PTS分子标志物、脂质过氧化损伤以及内皮功能等一系列变化 ,并且这种变化在合并DM的患者更为明显。
Objective To observe the changes of prethrombotic state (PTS) markers in patients with coronary heart disease (CAD) and diabetes mellitus (DM) before and after coronary intervention. Methods 32 patients with CAD (group A) and 24 patients with non-insulin-dependent diabetes mellitus (NIDDM, group B) underwent coronary artery intervention. Blood samples were collected before and at 20 min, 24 h and 7 d after operation to determine PTS Molecular markers, lipid peroxides (LPO) and vascular endothelial function. Results The postoperative PTS molecular markers, LPO and endothelial function were significantly changed in both groups, and the changes in group B were more obvious. At the 7th day after operation, the level of PTS returned to the preoperative level in group A obvious change. Conclusion There are a series of changes of PTS molecular markers, lipid peroxidation injury and endothelial function after intervention in CAD patients, and this change is more obvious in patients with DM.