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1,3-β-D-葡聚糖广泛存在于各类真菌细胞壁中,是细胞壁的重要组成部分之一。研究表明,除少数真菌外,所有真菌细胞壁上都含有1,3-β-D-葡聚糖,以酵母样真菌含量最高。当真菌进入人体血液或深部组织,经吞噬细胞吞噬、消化后,1,3-β-D-葡聚糖可从胞壁中释放出来,其在血液及其他体液(如尿、脑脊液、腹水、胸腔积液等)中的含量增加。因此,1,3-β-D-葡聚糖已成为检测真菌感染的一个有意义的指标。国内、外早在20世纪80年代就开始对1,3-β-D-葡聚糖的定量检测方法进行
1,3-β-D-glucan is widely found in various fungal cell walls and is an important part of the cell wall. Studies have shown that, except for a few fungi, all fungal cell walls contain 1,3-β-D-glucan to yeast-like fungi highest content. When the fungus enters human blood or deep tissues and is phagocytosed and phagocytosed by phagocytes, 1,3-β-D-glucan can be released from the cell wall in the blood and other body fluids such as urine, cerebrospinal fluid, ascites, Pleural effusion, etc.) in the content increased. Therefore, 1,3-β-D-glucan has become a meaningful indicator of fungal infection detection. The method of quantitative determination of 1,3-β-D-glucan was started at home and abroad as early as the 1980s