Although the anatomical configuration of the amygdala has been studied a greatdeal,very little research has been conducted on understanding the precise mecha-nism by which this emotional regulatory center exerts its control on emotional andsexual behavior.By applying research methodology from the Neuroscience Re-search Institute,State University of New York,College at Old Westbury,we in-tended to demonstrate that much of the mediated effects of the amygdala,specifi-cally the regulation of the male and female sexual response cycles,as well asrelated emotional considerations,exert their effects coupled to nitric oxide (NO)release.Furthermore,by using current anatomical and histological data,wedemonstrated that amygdalar tissue rich in endocannabinoid and opiate,as wellas catecholamine,receptors could exert its neurochemical effects within an NO-mediated paradigm.This paradigm,together with the existence of estrogen andandrogen signaling within the amygdala,further lends credence to our theoreticalframework.We begin with a brief anatomical and functional review of amygdalarfunction,and then proceed to demonstrate its relationship with NO. Although the anatomical configuration of the amygdala has been studied a greatdeal, very little research has been conducted on understanding the precise mecha-nism by which this emotional regulatory center exerts its control on emotional andsexual behavior. By applying research methodology from the Neuroscience Re-search Institute, State University of New York, College at Old Westbury, we in-tended to demonstrate that much of the mediated effects of the amygdala, specifi-cally the regulation of the male and female sexual response cycles, as well as dependent emotional considerations, exert their effects coupled to nitric oxide (NO) release. Future mods, by using current anatomical and histological data, wedemonstrated that amygdalar tissue rich in endocannabinoid and opiate, as wellas catecholamine, receptors could exert its neurochemical effects within an NO-mediated paradigm. This paradigm together with the existence of estrogen and androgen signaling within the amygdala, further lends credence to our t heoreticalframework.We begin with a brief anatomical and functional review of amygdalarfunction, and then proceed to demonstrate its relationship with NO.