论文部分内容阅读
目的了解广西女性性工作者(FSWs)对艾滋病病毒(HIV)暴露前药物预防(PrEP)临床试验的参与意愿及其影响因素。方法采用横断面调查方法于2009年11月—2010年2月在广西南宁市、柳州市、北海市共招募348名FSWs进行问卷调查。结果 348名调查对象中PrEP的知晓率为14.9%(52/348);54.3%(189/348)的FSWs表示愿意参加PrEP临床试验,不愿意参加的主要原因是:81.8%(130/159)的FSWs担心PrEP的副作用,42.8%(68/159)的FSWs担心PrEP无效果,27.7%(44/159)的FSWs认为自己没有感染HIV的危险,没必要参加;近半年与嫖客、配偶/固定性伴、临时性伴(不付费)发生性行为时每次都使用安全套者分别占78.4%(273/348)、25.2%(67/266)、70.9%(134/189);多因素logistic回归分析结果表明,PrEP临床试验的影响因素为目前居住地、能坚持每天服用药物、认为有能力预防HIV感染、与家人的关系好、场所业主会影响选择服用药物、担心使用药物被他人歧视。结论场所业主、家人的支持及他人的歧视是广西FSWs参与PrEP临床试验的重要影响因素,联合干预和减少歧视可能是提高其参与意愿的有效措施。
Objective To understand the willingness of Chinese women’s sexual workers (FSWs) to participate in pre-HIV drug prevention (PrEP) clinical trials and their influencing factors. Methods A total of 348 FSWs were recruited from Nanning, Liuzhou and Beihai in Guangxi from November 2009 to February 2010 by means of cross-sectional survey. Results The awareness rate of PrEP in 348 subjects was 14.9% (52/348). FSWs of 54.3% (189/348) were willing to participate in the PrEP clinical trial. The main reasons for the unwillingness to attend were: 81.8% (130/159) Of FSWs worried about the side effects of PrEP, 42.8% (68/159) of FSWs worried about PrEP no effect, 27.7% (44/159) FSWs thought they had no risk of HIV infection, no need to participate; nearly six months with clients, spouses / Sexual partners, temporary partners (not paying) accounted for 78.4% (273/348), 25.2% (67/266) and 70.9% (134/189) respectively when they had sexual intercourse. Multivariate logistic regression The results showed that the factors influencing PrEP clinical trial were current living place, persisting in daily taking of drugs, being able to prevent HIV infection and having good relationship with family members, and the place owners affected the choice of taking drugs and worried that the use of drugs was discriminated against by others. Conclusions The support of place owners, family members and others is an important factor for Guangxi FSWs to participate in PrEP clinical trials. Joint intervention and reduction of discrimination may be effective measures to increase their willingness to participate.