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目的:研究非诺贝特对单核细胞以及外膜血管增生的抑制作用。方法:把仔猪12头的24支冠状动脉制成冠脉气囊损伤支架置入模型,然后分为非诺贝特组和对照组,使用血管内超声、电镜等仪器,并采用病理组织学等方法进行观察。结果:1支架置入后第3d的单核细胞的浸润:非诺贝特组明显少于对照组;2支架置入第28d的冠脉内腔面积,血管面积:非诺贝特组的血管面积明显大于对照组(7.05±0.43∶6.32±0.24,P=0.035),内腔面积也明显大于对照组(5.95±0.76∶4.76±0.37,P=0.040);3血管重构指数,内膜肥厚:非诺贝特组的血管重构指数明显大于对照组(1.13±0.45∶0.75±0.47,P=0.032)。但是内膜肥厚的面积却明显小于对照组(1.10±0.45∶1.95±0.43,P=0.042);4支架置入28d后的外膜新生血管情况:非诺贝特组明显小于对照组(3.20±0.11∶7.01±0.23,P=0.038)。结论:非诺贝特对猪冠状动脉气囊损伤支架置入模型早期的单核细胞以及外膜血管增生具有抑制作用,从而阻止了收缩性血管重组的形成。
OBJECTIVE: To study the inhibitory effect of fenofibrate on the proliferation of monocytes and adventitial vessels. Methods: 24 coronary arteries of 12 piglets were implanted into the model of coronary balloon injury, and then divided into fenofibrate group and control group, using intravascular ultrasound, electron microscope and other methods, and using histopathological methods Observe. Results: 1 Infiltration of mononuclear cells on the 3rd day after stenting: the fenofibrate group was significantly less than that of the control group; the second stent was placed on the coronary lumen area on the 28th day. The area of the vessel was: fenofibrate (7.05 ± 0.43:6.32 ± 0.24, P = 0.035), and the lumen area was also significantly larger than that of the control group (5.95 ± 0.76:4.76 ± 0.37, P = 0.040) .3 The vascular remodeling index, intima-media thickness : The fenofibrate group had a significantly higher vascular remodeling index than the control group (1.13 ± 0.45: 0.75 ± 0.47, P = 0.032). However, the area of endometrial hypertrophy was significantly smaller than that of the control group (1.10 ± 0.45: 1.95 ± 0.43, P = 0.042). The adventitial neovascularization after stent implantation for 28 days was significantly lower in fenofibrate group than that in control group (3.20 ± 0.11: 7.01 ± 0.23, P = 0.038). Conclusion: Fenofibrate can inhibit the formation of contractile vascular remodeling by inhibiting the proliferation of monocytes and adventitial vasculature in the early stage of implantation of porcine coronary artery balloon.