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目的探讨透明质酸在妇产科腹盆腔手术术后粘连预防中的临床效果。方法选取来我院2011年6月至2013年4月采取妇产科腹盆腔手术治疗的患者100例,将其随机分为两组,观察组和对照组各50例。两组患者均采取妇产科腹盆腔手术进行治疗,观察组50例患者在手术过程中给与透明质酸进行术后粘连的预防。结果观察组初次手术患者与再次手术患者的粘连发生率与重度粘连发生率均显著低于对照组患者,比较差异具有统计学意义(P<0.05)。观察组患者术前的血清IL-6、IL-10、TNF-α、CRP水平与对照组患者相比,比较差异不具有统计学意义(P>0.05)。观察组患者术后的血清IL-6、IL-10、TNF-α、CRP水平均显著低于对照组患者,比较差异具有统计学意义(P<0.05或P<0.01)。结论采取在妇产科腹盆腔手术中采取透明质酸预防术后粘连能够显著降低粘连发生率和重度粘连发生率,显著降低该患者的血清IL-6、IL-10、TNF-α、CRP水平。
Objective To investigate the clinical effect of hyaluronic acid in the prevention of adhesion after abdominal pelvic surgery in obstetrics and gynecology. Methods A total of 100 patients who underwent abdominal pelvic surgery in our department from June 2011 to April 2013 were selected and randomly divided into two groups, 50 cases in observation group and control group. Two groups of patients were treated with obstetrics and gynecology abdominal pelvic surgery, observation group of 50 patients with hyaluronic acid during surgery to prevent postoperative adhesions. Results The incidence of adhesions and severe adhesions in the primary surgical patients and reoperation patients in the observation group were significantly lower than those in the control group, with statistical significance (P <0.05). The serum levels of IL-6, IL-10, TNF-α and CRP in the observation group before operation were not significantly different from those in the control group (P> 0.05). The serum levels of IL-6, IL-10, TNF-α and CRP in the observation group were significantly lower than those in the control group (P <0.05 or P <0.01). Conclusion Adopting hyaluronic acid to prevent postoperative adhesions in obstetrics and gynecology abdominal pelvic surgery can significantly reduce the incidence of adhesion and severe adhesion, and significantly reduce the serum IL-6, IL-10, TNF-α and CRP levels .