肝源性IR是T2DM重要发病基础之一,机制主要为受体缺陷及信号转导异常。作为对抗胰岛素的重要激素,胰升血糖素在糖尿病发病中起重要作用。与健康人群比,糖尿病患者或动物存在胰岛素异常分泌,也存在胰升血糖素异常高分泌。胰升血糖素在肝源性IR中的作用主要为抑制肝糖原合成及糖酵解,促进肝糖原分解、糖异生及脂肪分解。 Hepatic IR is one of the important pathogenesis of T2DM. The mechanisms are mainly receptor defects and signal transduction abnormalities. As an important hormone against insulin, glucagon plays an important role in the pathogenesis of diabetes. Compared with healthy people, patients with diabetes or abnormal insulin secretion exist, but also the abnormal secretion of glucagon abnormalities. The role of glucagon in liver-derived IR is mainly to inhibit glycogen synthesis and glycolysis, promote glycogenolysis, gluconeogenesis and lipolysis.