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对伴有爱滋病(AIDS)的隐球菌性脑膜炎最理想的临床治疗措施尚不清楚。但不具AIDS的此类疾病,传统疗法联用两性霉素B和氟胞嘧啶进行治疗。其原因之一是两性霉素B对脑部穿透力较差,氟胞嘧啶能迅速通过血脑屏障。但因氟胞嘧啶具有骨髓抑制作用,从而限制它在伴有爱滋病隐球菌性脑腹炎患者中的应用。因此有些医生仅单用两性霉素B来治疗上述疾病。由于隐球菌性脑腹炎患者经常复发,因
The most ideal clinical treatment for cryptococcal meningitis associated with AIDS remains unclear. However, these diseases are not AIDS, the traditional therapy combined with amphotericin B and flucytosine for treatment. One of the reasons for this is that amphotericin B has poor penetrating power to the brain and flucytosine quickly passes through the blood-brain barrier. However, flucytosine has a myelosuppressive effect, thereby limiting its use in patients with cryptococcal AIDS with cryptococcosis. Therefore, some doctors only amphotericin B to treat the above diseases. Due to frequent recurrent cryptococcal brain inflammation patients, due