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目的探讨冠心病合并2型糖尿病心功能不全血浆B型钠尿肽水平(BNP)变化的意义。方法采用免疫荧光法测定63例冠心病合并2型糖尿病心功能不全(观察组)及62例冠心病心功能不全患者(对照组)血浆的BNP水平,并用心脏超声测定左室射血分数(LVEF)数值,以了解左心室功能,然后对两组数据进行临床对比分析。结果观察组BNP水平明显高于对照组,而观察组LVEF值低于对照组(P<0.05)。观察组住院时间更长。结论观察组BNP水平、LVEF值与对照组比较有统计学意义。因此,对冠心病合并2型糖尿病心功能不全患者,可以通过血浆BNP水平的测定,早期准确地诊断心力衰竭及判断心衰分级,以利于临床上及时有效地调整治疗方案,尽早纠正心衰,缩短住院时间,减少病死率。
Objective To investigate the significance of plasma B-type natriuretic peptide (BNP) in patients with coronary heart disease complicated with type 2 diabetes. Methods Plasma BNP levels were measured by immunofluorescence in 63 patients with coronary heart disease complicated with type 2 diabetes mellitus (observation group) and 62 patients with coronary heart disease (control group). The left ventricular ejection fraction (LVEF) ) Values to understand left ventricular function, and then two sets of data for clinical comparative analysis. Results The level of BNP in the observation group was significantly higher than that in the control group, while the LVEF in the observation group was lower than that of the control group (P <0.05). Observation group hospitalization longer. Conclusion The levels of BNP and LVEF in the observation group have statistical significance compared with the control group. Therefore, coronary heart disease patients with type 2 diabetes mellitus, can be determined by plasma BNP levels, early and accurate diagnosis of heart failure and heart failure classification, in order to facilitate timely and effective clinical adjustment of treatment programs, as soon as possible to correct heart failure, Shorten hospital stay and reduce mortality.