产Vero毒素(VT)的大肠杆菌(VTEC)可能是肠致病性溶血尿毒综合征(HUS)、出血性结肠炎的病原。不少研究表明循环VT选择性破坏内皮细胞,导致HUS和出血性结肠炎的血栓性微血管病变。Tayloy等证实红细胞上的P_1抗原强度与典型HUS后果有一定的联系。P_1抗原可能是VT的受体,但VTs与红细胞的结合有待证明。作者研究了VTs与人红细胞在体外的结合,并探讨了这种结合是否与红细胞P表型有关。用VT的 Escherichia coli (VTEC) producing Vero toxin (VT) may be the causative agent of enteropathogenic hemolysis uremic syndrome (HUS) and hemorrhagic colitis. Numerous studies have shown that circulating VT selectively damages endothelial cells, leading to thrombotic microvascular lesions of HUS and hemorrhagic colitis. Tayloy et al. Demonstrated that the intensity of P 1 antigen on erythrocytes is related to typical HUS consequences. The P1 antigen may be a VT receptor, but the binding of VTs to erythrocytes remains to be demonstrated. The authors studied the in vitro binding of VTs to human erythrocytes and explored whether this binding is associated with erythrocyte P phenotype. With VT