美国 Dartmouth 医学院(DMS)的两项研究结果显示,一种可吸收大量血管生成分子和阻断癌细胞抗药信号通道的蛋白海绵可改善胰腺癌的疗效。正如人们所知,胰腺癌的快速播散可归因于对传统化疗药物的耐受性增高,因此通常被确诊的晚期胰腺癌的治疗希望微乎其微。来自于美国 DMS 的内科主任 Murray Korc 医生指出,当胰腺癌一旦被确诊时,胰腺癌细胞就已具有极大的超出正常细胞的增长速度,进而使其快速生长和播散。Korc 医生研究小组旨在确定哪些因素能使癌细胞增长如此快速,同时它们又是减速和抑制胰腺肿瘤生长的机制。首先,研究人员将注意力集中于阻碍化疗药物作用的血管内皮生长因子(VEGF)分子的过度表达。研究证实 VEGF 作用于血管生成,在胰腺癌细胞中的水平高于正常细胞含量的90倍以上,从而使癌细胞得以快速高效地增长并转移。将一种蛋白海绵 VEGF-Trap 注射到1只携带4种不同人类胰腺癌细胞衍生的小鼠胰腺肿瘤体中;研究人员预示这种蛋白海绵能够吸收大量的 VEGF血管生成分子,并减缓癌细胞的血管增殖以抑制肿 Two studies by the Dartmouth Medical School (DMS) in the United States have shown that a protein sponge that absorbs large numbers of angiogenic molecules and blocks the drug resistance of cancer cells can improve the efficacy of pancreatic cancer. As is known, the rapid spread of pancreatic cancer can be attributed to increased tolerance to traditional chemotherapeutic drugs, and the treatment of advanced pancreatic cancer, which is usually diagnosed, is therefore hopelessly minimal. Murray Korc, MD, director of internal medicine at DMS in the United States, points out that once pancreatic cancer is diagnosed, the pancreatic cancer cells already have a tremendous rate of growth beyond normal cells, allowing them to grow and spread rapidly. Dr. Korc’s team is working to determine what factors make cancer cells so fast, and at the same time they are the mechanisms that slow down and inhibit pancreatic tumor growth. First, the researchers focused their attention on overexpression of vascular endothelial growth factor (VEGF) molecules that block the effects of chemotherapeutic drugs. Studies have shown that VEGF acts on angiogenesis, which is more than 90 times higher than normal cells in pancreatic cancer cells, allowing cancer cells to grow and metastasize rapidly and efficiently. One protein sponge, VEGF-Trap, was injected into a mouse pancreatic tumor that carries four different human pancreatic cancer-derived tumors; researchers predict that this protein sponge can absorb a large number of VEGF angiogenic molecules and slow down cancerous Vascular proliferation to inhibit swelling