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Cefpirome(HR810)是新的第三代头孢菌素类抗生素,抗流感嗜血菌、奈瑟氏球菌作用好,由于在哺乳妇女的乳汁中有分布进而进入婴儿中。本法采取异丙醇提取后微柱HPLC测定乳汁及尿液中Cefpirome,具快速简便的特点。色谱条件Hewlett—Packard 1090L型液相仪,ODS柱(10cm×2.1mmID5μ),柱温50℃,流动相组成为甲醇和0.3%三乙胺
Cefpirome (HR810) is a new third-generation cephalosporin antibiotic that is resistant to H. influenzae and Neisserial bacteria and enters infants as it is distributed throughout breast milk from lactating women. This method adopts isopropanol extraction after micro column HPLC determination of milk and urine Cefpirome, with fast and easy features. Chromatographic conditions Hewlett-Packard 1090L liquid phase instrument, ODS column (10cm × 2.1mmID5μ), the column temperature 50 ℃, the mobile phase consisting of methanol and 0.3% triethylamine