P53肿瘤抑制基因的缺失、点突变是迄今发现的胶质瘤最常见的分子生物学改变。近来的研究表明,星形细胞瘤P53基因突变率较其它类型的胶质瘤高,胶质瘤P53基因突变多分布于第4—8外显子上,以错义突变为主,常常合并另一等位基因杂合性丢失。P53基因的缺失、突变和胶质瘤的病理级别、增殖能力有关。免疫组化研究显示,恶性胶质瘤常常存在P53蛋白过度表达。本文就此方面的进展及面临的问题作一概述。 P53 tumor suppressor gene deletion, point mutation is the most common so far found molecular changes in glioma. Recent studies have shown that astrocytoma P53 gene mutation rate higher than other types of gliomas, glioma P53 gene mutations are more in the first 4-8 exons, the missense mutation, often combined with another Loss of allele heterozygosity. P53 gene deletion, mutation and pathological grade of glioma and proliferation ability. Immunohistochemical studies have shown that malignant gliomas often exist P53 protein overexpression. This article gives an overview of the progress and problems in this area.