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将５％四氧嘧啶（ａｌｏｘａｎ）按２００ｍｇ／ｋｇ体重经前腔静脉注射入小型猪体内，分别于４、７、１１、１９、２４、３６、４８、７２、９６、１２０ｈ测定小型猪血液生化指标；并于注射四氧嘧啶后７２ｈ进行糖耐量实验，最后做形态学检查。结果表明受试组血糖明显高于对照组，且糖耐量异常。注射四氧嘧啶后的２～３天，受试组血清总蛋白量呈下降趋势；受试组尿糖转阳，而对照组尿糖阴性。病理形态学所见，肾上腺皮质束状区上皮细胞变性，胞浆空泡状，部分区域核浓染；皮质网状区上皮细胞呈空泡状。而两组猪的胰、心肌、肝、脾、肺、胃、肠、主动脉、甲状腺等器官未见异常
5% aloxan (200mg / kg body weight) was injected into the mini-pig through the anterior vena cava, and the mini-pig’s blood biochemistry was determined at 4,7,11,19,24,36,48,72,96,120 h Indicators; and after alloxan injection 72h glucose tolerance test, the final morphological examination. The results showed that the test group was significantly higher than the control group, and impaired glucose tolerance. 2 to 3 days after injection of alloxan, serum total protein in the test group showed a downward trend; test group urine sugar turn positive, while the control group, urine negative. Pathological morphology, adrenal cortical epithelial cells degeneration, vacuolar cytoplasm, nuclear staining in some areas; cortical reticular epithelial cells were vacuolar. The two groups of pigs, pancreas, myocardium, liver, spleen, lung, stomach, intestine, aorta, thyroid and other organs were not abnormal