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目的探讨胸水中多项肿瘤标志物的联检对鉴别良恶性胸水的临床价值。方法采用电化学免疫分析法检测28例癌性胸水和40例炎性胸水中的CEA、CA125、CA153、SF等四种肿瘤标志物含量进行对比分析。结果癌性胸水组CEA、CA125、CA153、SF四项肿瘤标志平均水平、阳性率均显著高于炎性胸水组(P<0.01),四种指标联检对癌性胸水的诊断阳性率可达92.86%。结论胸水CEA、CA125、CA153、SF联合检测可显著提高癌性胸水的阳性诊断率,对鉴别良恶性胸水有重要价值。
Objective To investigate the clinical value of multiple tumor markers in pleural effusion for differential diagnosis of benign and malignant pleural effusions. Methods The CEA, CA125, CA153, SF and other tumor markers in 28 cases of cancerous pleural effusion and 40 cases of inflammatory pleural effusion were detected by electrochemical immunoassay. Results The average level of the four tumor markers CEA, CA125, CA153 and SF in cancerous pleural effusion group were significantly higher than those in inflammatory pleural effusion group (P <0.01). The positive rates of the four markers in detecting pleural effusion were 92.86 %. Conclusions The combined detection of CEA, CA125, CA153 and SF in pleural effusion can significantly improve the positive diagnostic rate of cancerous pleural effusion, which is of great value in differential diagnosis of benign and malignant pleural effusion.