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目的通过大鼠的脊髓损伤模型,观察和探讨促神经因子保护剂N6对于脊髓损伤后运动功能的恢复作用和临床疗效,以期为进一步的研究提供思路和相关理论基础。方法 2017年3月将40只雄性SD大鼠平均随机分为4组,每组为10只。按照治疗方法的不同,分别分为:鸡尾酒促神经因子保护剂N6给药组(Cocktail组),甲强龙组(MP组),假手术组(Sham组)和单纯脊髓损伤组(SCI组)。前两组在建立大鼠脊髓损伤模型后10min即给予相应的药物。在建模及之后每隔7d观察和记录不同组大鼠的后肢功能运动评分(Basso-Beattie-Bresnahan,BBB评分)。结果 Sham组的大鼠BBB评分在建模后始终高于其余3组。Cocktail组和MP组在建模7dBBB评分高于SCI组(P<0.05),但Cocktail组与MP组相比差异无统计学意义(P>0.05)。在建模14、21、28d,Cocktail组的BBB评分高于其他2组(P<0.05)。结论使用鸡尾酒神经保护剂N6进行脊髓损伤的治疗,有利于大鼠运动功能的恢复。在脊髓损伤的临床研究和治疗中可以进一步进行探索和推广。
Objective To observe and explore the recovery effect and clinical effect of prokinetic neuroprotectant N6 on motor function after spinal cord injury in rat model of spinal cord injury in order to provide ideas and relevant theoretical basis for further study. Methods March 2017 40 male SD rats were randomly divided into 4 groups, each group of 10. According to the different treatment methods, they were divided into Cocktail group, MP group, sham group and SCI group, respectively, . The first two groups in the establishment of rat model of spinal cord injury 10min after giving the appropriate drug. Hindlimb motor function scores (Basso-Beattie-Bresnahan, BBB score) were observed and recorded in different groups of rats at 7 days after modeling and thereafter. Results Sham group rats BBB score always higher than the remaining three groups after modeling. The 7dBBB score of Cocktail group and MP group was higher than that of SCI group (P <0.05), but there was no significant difference between Cocktail group and MP group (P> 0.05). BBB scores in Cocktail group were higher than those in other two groups at 14,21,28d (P <0.05). Conclusion The use of cocktail neuroprotective agent N6 in the treatment of spinal cord injury is conducive to the recovery of motor function in rats. In the clinical research and treatment of spinal cord injury can be further explored and promoted.