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目的 : 对 42例使用高三尖杉酯碱的急性白血病患者进行了临床药物动力学的研究 ,探索血药浓度及代谢动力学过程与疗效的关系。方法 :应用 HPL C测定患者血清中高三尖杉酯碱的血药浓度。结果 :高三尖杉酯碱在体内为二房室分布 ,药代动力学在不同个体间差异显著 ,与化疗疗效有关的参数是 K12 / K2 1,有效和无效组间差异非常显著 ,单独给药与联合用药组药代参数无显著差异。结论 :分析表明 K12 / K2 1与疗效呈负相关 (P<0 .0 1)
Objective : To study the clinical pharmacokinetics of 42 cases of acute leukemia patients using homoharringtonine to explore the relationship between plasma concentration and metabolic process and efficacy. Methods : HPL C was used to determine the plasma concentration of homoharringtonine in patients. RESULTS: Homoharringtonine was distributed in the second compartment of the body, and the pharmacokinetics was significantly different among different individuals. The parameter related to the efficacy of chemotherapy was K12/K2 1. The difference between the effective and ineffective groups was very significant. There was no significant difference in the pharmacokinetic parameters of the combination group. Conclusion: The analysis showed a negative correlation between K12/K2 1 and efficacy (P<0.01).