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Based on Fuller's model, a gradation design is presented for the load-carrying capacity of an asphalt mixture with stone-to-stone contact. The coarse aggregate gradation, fine aggregate and filler gradation are respectively designed for their different effects on an asphalt mixture with stone-to-stone contact. The equation of coarse aggregate gradation is deduced from the Fuller's model. Fine aggregate gradation is calculated by using Fuller's equation. The asphalt mixture with the 16 mm maximum size of aggregate is verified. When the coefficient of coarse aggregate gradation is 0.35 and fine aggregate gradation is 0.25, the volume parameters of asphalt mixture meet the technical specifications. Moreover, the high temperature stability and crack resistance at low temperature are all well.