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目的:对于戊酸雌二醇配伍米非司酮和米索前列醇治疗稽留流产的临床效果进行对比探讨。方法:选取我院于2014年4月-2016年4月间收治的100例稽留流产病例临床资料,按照临床治疗方式的不同分为对照组与实验组(各50例),前者接受口服米非司酮和米索前列醇治疗,后者接受口服戊酸雌二醇配伍米非司酮和米索前列醇治疗。经一定周期,对于两组产妇出血量(均为服用6h后)、胚胎分娩结果展开对比。结果:与对照组相比,实验组娩出率显著增加[前者为64.0%(32例),后者为86.0%(43例)],P<0.05;娩出时长显著缩短[对照组(5.4±1.0)h、实验组(3.6±0.7)h]。同时实验组产妇出血量有效降低[对照组(75.4±14.7)ml、实验组(55.2±10.6)ml],P<0.05。结论:临床采用戊酸雌二醇配伍米非司酮和米索前列醇对于有效改善稽留流产病例娩出率,缩短娩出时长,并降低总出血量具有显著价值,能够使病人痛苦程度降低,因此值得临床研究与推广应用。
OBJECTIVE: To compare the clinical effects of estradiol valerate with mifepristone and misoprostol in the treatment of missed abortion. Methods: The clinical data of 100 cases of missed abortion admitted in our hospital from April 2014 to April 2016 were divided into control group and experimental group (50 cases in each group) according to the different clinical treatment methods. The former received oral Mifei Ketones and misoprostol, the latter receiving oral administration of estradiol valerate in combination with mifepristone and misoprostol. After a certain period, for the two groups of maternal bleeding (both after taking 6h), embryo delivery results contrast. Results: Compared with the control group, the delivery rate in the experimental group increased significantly (64.0% (32 cases) and 86.0% (43 cases) in the experimental group], P <0.05; the duration of delivery was significantly shortened [5.4 ± 1.0 ) h, experimental group (3.6 ± 0.7) h]. At the same time, the amount of maternal bleeding in the experimental group was significantly reduced (75.4 ± 14.7 ml in the control group and 55.2 ± 10.6 ml in the experimental group, P <0.05). Conclusion: The clinical use of estradiol valerate in combination with mifepristone and misoprostol has significant value in improving the delivery rate of patients with missed abortion, shortening the delivery time and reducing the total amount of bleeding, which can reduce the degree of patient pain, so it is worth Clinical research and popularization and application.