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睾丸间质细胞 (Leydigcells,LC)的发生与成熟过程都和细胞凋亡相关 ,一定范围内的凋亡对机体具有积极的生理意义 ,但过度凋亡会使睾酮 (T)分泌明显减少 ,导致生精细胞凋亡增加 ,甚至不育。二甲磺基乙烷 (ethanedimethane sulphonate,EDS) ,糖皮质激素 ,下丘脑 垂体 睾丸轴分泌的促性腺激素释放激素 (GnRH)、卵泡刺激素 (FSH)、黄体生成素 (LH) /绒毛膜促性腺激素 (hCG)、T等激素 ,LC发育阶段及其他一些因素都会影响其凋亡。多个基因参与LC凋亡的调控 ,SCF/c kit、Bcl 2、Bcl xl可抑制其凋亡 ,caspase 3、Fas、Bax和clusterin可促进其凋亡
The occurrence and maturation of Leydig cells (LC) are related to apoptosis. A certain range of apoptosis has positive physiological significance to the body, but excessive apoptosis leads to a marked decrease of testosterone (T) secretion, leading to Spermatogenic cell apoptosis increased, or even infertile. Ethanedimethane sulphonate (EDS), glucocorticoids, gonadotropin releasing hormone (GnRH), follicle stimulating hormone (FSH), luteinizing hormone (LH) / chorionic gonadotropin Hormone (hCG), T and other hormones, LC developmental stage and other factors will affect its apoptosis. Multiple genes involved in the regulation of LC apoptosis, SCF / c kit, Bcl 2, Bcl xl can inhibit its apoptosis, caspase 3, Fas, Bax and clusterin can promote apoptosis