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441例线虫感染者分成两大组。甲组:其中111人感染蛔虫56人.钩虫102人,应用丙硫咪唑300mg顿服及噻嘧啶300mg分两次服,治后3周及5月复查,全阴转率73.9％及61.3％,其中蛔虫阴转率98.2％及81.5％,钩虫92.2％及94.7％;另有109人感染蛔虫95人、钩虫96人及鞭虫98人,用上述两药外加酚嘧啶450mg分两次服,治后全阴转率70.6％及67.0％,其中蛔虫98.9％及88.3％,钩虫92.7％及90.1％,鞭虫87.8％及95.8％。乙组:其中120人感染蛔虫44人,钩虫107人,用丙硫唑咪600mg顿服,全阴转率75.8％及56.7％,蛔虫100.0％及88.6％,钩虫88.8％及79.6％;另有101人感染蛔虫91人、钩虫88人,鞭虫95人,用丙硫咪唑600mg顿服及酚嘧啶450mg分两次服,治后全阴转率72.3％及50.5％,蛔虫94.5％及86.9％,钩虫84.1％及86.2％,鞭虫93.7％及93.3％。虫卵减少率各组均达90％以上至100％。各药配伍均未见明显副反应。
441 cases of nematode infection were divided into two groups. Group A: 111 of them were infected with roundworm, and there were 102 hookworm, 300mg of dipivoxil and 300mg of pyrimethamine were administered twice in two cycles, and the total negative conversion rate was 73.9% and 61.3% respectively after 3 weeks and 5 months of treatment. Infection rate of roundworm was 98.2% and 81.5% respectively, hookworm was 92.2% and 94.7% respectively. Another 109 were infected with 95 roundworms, 96 hookworm and 98 whipworm. After the total negative conversion rate of 70.6% and 67.0%, of which roundworms 98.9% and 88.3%, hookworms 92.7% and 90.1%, whipworm 87.8% and 95.8%. Group B: 44 of them were infected with 120 roundworms, 107 were hookworm, 600 mg of propylthiazamide, and 75.8% and 56.7% of the total negative conversion rate respectively, 100.0% and 88.6% of roundworms, 88.8% and 79.6% of hookworms respectively 101 people were infected with 91 roundworms, 88 hookworms, 95 whipworms, and 600mg of albendazole and 450mg of phenopyrimidine were administered in two doses. After treatment, the rates of total negative conversion were 72.3% and 50.5%, 94.5% and 86.9% , Hookworms 84.1% and 86.2%, whipworms 93.7% and 93.3%. Egg reduction rate of each group reached more than 90% to 100%. The compatibility of each drug were no obvious side effects.