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[目的]观察真武汤联合西药治疗儿童重症手足口病疗效。[方法]使用随机平行对照方法,将24例住院患者按病志号抽签方法简单随机分为两组;卧床休息,加强营养补液,布洛芬,口腔护理。对照组12例更昔洛韦5mg/kg+5%葡萄糖100mL,2次/d,静滴;感染加头孢他啶100mg/kg+5%葡萄糖100mL,2次/d,静点,最大剂量<6g/d。治疗组12例真武汤(附子泡、煎各1h35g,白芍、生白术、生姜各10g,茯苓15g,肉桂3g,生地15g;上焦热明显,舌尖红,脉滑数有力加竹叶、通草、生甘草各5g;厌食,舌淡红,苔白厚腻,去生白术,加砂仁5g,苍术、蔻仁、神曲各10g;高热脉沉弱,加乌梅15g,干姜10g),水煎200mL,1剂/d,分5次服。治疗5d为1疗程。观测临床症状、皮疹、精神状态、肢体抖动、发热恢复时间、不良反应。治疗1疗程(5d),判定疗效。[结果]治疗组痊愈9例,好转3例,无效0例,总有效率100.00%;对照组痊愈7例,好转5例,无效0例,总有效率100.00%,治疗组疗与对照组具有等效性(P>0.05)。皮疹、肢体抖动、体温恢复正常时间治疗组短于对照组(P<0.01),精神状态恢复时间两组间无明显差异(P>0.05)。[结论]真武汤联合西药治疗儿童重症手足口病,与西药治疗具有等效性,无严重不良反应,值得深入研究。
[Objective] To observe the therapeutic effect of Zhenwu Decoction combined with Western medicine on severe hand-foot-mouth disease in children. [Methods] Twenty-four inpatients were randomly divided into two groups randomly by randomized parallel control. Patients in bed rest, nutrition rehydration, ibuprofen and oral care were randomly divided into two groups. In the control group, 12 patients were treated with ganciclovir 5mg / kg + 5% glucose 100mL twice daily for 12 days. The patients were infected with ceftazidime 100mg / kg and 5% d. In the treatment group, 12 cases of Zhenwu Decoction (aconite bubble, fried 1h35g, white peony root, raw Atractylodes, ginger 10g, Poria 15g, cinnamon 3g, habitat 15g; , Raw licorice 5g; anorexia, pink tongue, white thick and greasy coating, to Atractylodes, add Amomum 5g, herb, Kou Ren, Divine Comedy each 10g; high heat pulse Shen weak, Garume 15g, ginger 10g), water Fried 200mL, 1 / d, divided into 5 times service. 5d treatment for a course of treatment. Observation of clinical symptoms, rash, mental state, limb jitter, fever recovery time, adverse reactions. Treatment of 1 course of treatment (5d), determine the efficacy. [Results] In the treatment group, 9 cases were cured, 3 cases were improved, 0 was ineffective and the total effective rate was 100.00%. In the control group, 7 cases were cured, 5 cases were improved, 0 was ineffective and the total effective rate was 100.00% Equivalent (P> 0.05). Rash, limb jitter, body temperature recovery time was shorter in the treatment group than in the control group (P <0.01), and there was no significant difference between the two groups in recovery time of mental status (P> 0.05). [Conclusion] Zhenwu decoction combined with Western medicine in children with severe hand-foot-mouth disease is equivalent to Western medicine and has no serious adverse reactions, which deserves further study.