环孢霉素(cyclosporine)对许多口腔粘膜病有效,但全身应用因剂量大而有许多副作用。局部应用虽减少了副作用的发生。但药物渗透性对疗效有一定的限制。药剂Zilactin(phoenix,Ariz)可形成一种含有羟丙基纤维素的薄膜,它是一种生物粘性膜,具有粘着粘膜和缓解疼痛的作用。作者评价了溶于Zilactin中的环孢霉素局部应用对治疗顽固性口腔苔藓样反应的效果。 14例特发性口腔扁平苔藓和4例同源骨髓移植后 Cyclosporine is effective for many oral mucosal diseases but systemic effects have many side effects due to its large dosage. Although the local application reduces the incidence of side effects. However, drug permeability has some limitations on the efficacy. The agent Zilactin (phoenix, Ariz) forms a film containing hydroxypropylcellulose, a bioadhesive film that has a clinging and pain-relieving effect. The authors evaluated the effect of a topical application of cyclosporin dissolved in Zilactin on the treatment of intractable oral moss-like reactions. 14 cases of idiopathic oral lichen planus and 4 cases of homologous bone marrow transplantation