多氯联苯诱导的六种鼠肝微粒体细胞色素P450重组酶系A_1,A_2,B,C_1,C_2和D对33种外来化合物代谢的催化速率不同,其中以C_1酶系和C_2酶系催化活力最强,其次为A_1酶系,B酶系催化活力最弱,外来化合物的种类不同,经重组酶系催化的途径也不同,如卤代烷烃,卤代烯烃,苯及其同系物,亚硝胺类等化合物主要经P450C_1酶系代谢,而大多数有机磷酸酯,氨基甲酸酯类化合物及多环芳烃类致癌物则以P450 C_2酶系代谢为主。 The catalytic rates of PCBs induced by PCBs A_1, A_2, B, C_1, C_2 and D to sixteen kinds of hepatic microsomal cytochrome P450 enzymes were different from those of the other compounds. Among them, C 1 and C 2 enzymes catalyzed Vitality is the strongest, followed by A_1 enzyme system, B enzyme system has the weakest catalytic activity, different types of foreign compounds, catalytic pathway by recombinant enzymes are also different, such as haloalkanes, haloolefins, benzene and its homologues, nitrite Amines and other compounds are mainly metabolized by the P450C1 enzyme system, while most of the organophosphates, carbamates and PAHs are metabolized by the P450 C_2 enzyme system.