由苯基格氏试剂对马来海松酸三甲酯选择性加成和水解反应,合成了一个新的手性酸,其结构均经元素分析、NMR、MS表征,前体甲酯结构通过COSY、HSQC和HMBC进行了分析,产物对3种不同胺的手性识别结果表明,与马来海松酸对比,产物对胺的识别效果有显著增强,有望作为手性识别试剂。 A new chiral acid was synthesized by the selective addition and hydrolysis reaction of phenyl Grignard onto trimethylmaleate. The structure of the precursor was characterized by elemental analysis, NMR and MS. The precursor methyl ester structure was identified by COZY , HSQC and HMBC were analyzed. The chiral recognition results of the products on three different amines showed that compared with the maleopimaric acid, the recognition effect of the product on the amine was significantly enhanced, which is expected to be used as a chiral recognition reagent.