乙型肝炎疫苗接种后可有效预防乙型肝炎,但远期效果如何,是否需要加强复种,仍是讨论的热点问题。本文介绍了近年来国内外在乙肝疫苗远期保护期限,影响保护效果的因素和加强接种的研究新进展,对于乙肝疫苗策略的制定有重要的参考价值。 Hepatitis B vaccination can effectively prevent hepatitis B, but the long-term effect, whether the need to strengthen the multiple cropping is still the hot issue of discussion. This article describes the recent years at home and abroad in the long-term protection of hepatitis B vaccine, the factors that affect the protection effect and strengthen the vaccination research progress, hepatitis B vaccine strategy formulation has important reference value.