论文部分内容阅读
目的：探讨同种异体尸肾移植术后肾小管性酸中毒（ＲＴＡ）的临床意义和发生机制。方法：将４５例肾移植患者按ＲＴＡ发生情况分成Ａ、Ｂ两组，比较其发生排斥反应情况，环孢素Ａ（ＣｓＡ）浓度等，并对ＲＴＡ组患者进行追踪观察。结果：肾移植术后发生ＲＴＡ较常见，多为可逆性，ＲＴＡ组出现的排斥反应次数较多。结论：肾移植术后ＲＴＡ的发生与低磷、高甲状旁腺激素（ＰＴＨ）血症、ＣｓＡ毒性等因素关系密切，对了解移植肾功能状态、预测排斥反应发生有一定价值。
Objective: To investigate the clinical significance and mechanism of renal allograft acidosis (RTA) after allogeneic cadaveric renal transplantation. Methods: Forty-five renal transplant recipients were divided into two groups according to the incidence of RTA. The incidence of rejection, the concentration of CsA and so on were compared. The patients in RTA group were followed up. Results: RTA occurred after renal transplantation was more common, mostly reversible, RTA group rejection occurred more frequently. CONCLUSION: The incidence of RTA after renal transplantation is closely related to low phosphorus, hyperparathyroid hormone (PTH) hyperlipidemia and CsA toxicity. It is of value in predicting renal allograft functional status and predicting the occurrence of rejection.