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静脉注射降钙素基因相关肽（ＣＧＲＰ），可使麻醉大鼠血压明显下降，在注射后１ｍｉｎ出现作用，５ｍｉｎ最明显（平均动脉压下降１５．５％），１０ｍｉｎ后恢复。在用药后心率最快时增加９．４％，持续３０ｍｉｎ，左室收缩压峰值和左室压上升最大速度分别增加１０％和１５％。ＣＧＲＰ的降压作用不能被阿托品阻断，且心率加快，心肌收缩性增强。预先用利血平阻断交感神经后再注射ＣＧＲＰ，心率无变化，平均动脉压、左室收缩压峰值、左室压上升最大速度均显著降低，且作用持续时间长。结果表明，ＣＧＲＰ的作用与交感神经的调控有密切关系．它的正性变力和变时的作用可能是通过交感神经释放递质引起的。
Intravenous calcitonin gene-related peptide (CGRP) can significantly reduce the blood pressure of anesthetized rats, 1 min after injection, the role of the most obvious 5min (mean arterial pressure decreased 15.5%), recovery after 10min. In the heart rate after treatment increased 9.4%, sustained 30min, left ventricular systolic blood pressure and left ventricular pressure increased the maximum speed increased by 10% and 15%. Antihypertensive effects of CGRP can not be atropine block, and heart rate, myocardial contractility increased. Presection of sympathetic blockade with reserpine after injection of CGRP, no change in heart rate, mean arterial pressure, peak systolic pressure, maximum velocity of left ventricular pressure were significantly reduced, and the role of long duration. The results show that the role of CGRP and the regulation of sympathetic are closely related. Its positive variable and time-varying effects may be caused by the sympathetic neurotransmitter release.