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目的 探讨过期妊娠孕妇血清β-HCG和 E3 含量与胎盘功能的关系并观察其形态学变化。方法 1采用放射免疫法分别测定过期妊娠和正常妊娠孕妇血清β-HCG和 E3 含量。 2分娩后取胎盘组织在光镜下观察胎盘绒毛结构变化。结果 1过期妊娠 NST无反应型或 OCT阳性组与正常妊娠组比较血清β-HCG含量明显增高 ,E3 含量明显降低( P均 <0 .0 1)。 2过期妊娠 NST无反应型或 OCT阳性组胎盘合体细胞结节、胎盘绒毛滋养细胞增生、绒毛基底膜增厚等改变明显高于正常妊娠组 ( P<0 .0 1)。结论 连续观察血清β-HCG变化可作为过期妊娠监测胎盘功能的一项重要指标
Objective To investigate the relationship between serum β-HCG and E3 levels and placental function in pregnant women with obesity and to observe their morphological changes. Method 1 The levels of serum β-HCG and E3 in pregnant women and normal pregnant women were determined by radioimmunoassay. 2 After delivery, placenta tissue was taken for observing the structure of placenta villi under light microscope. Results 1 Compared with the normal pregnancy group, the level of serum β-HCG and the content of E3 in NST non-responsive or OCT-positive group significantly increased (P <0.01). The changes of placental syncytial nodules, placental trophoblast proliferation and villus basement membrane thickening in NST non-responsive or OCT positive group were significantly higher than those in normal pregnancy (P <0.01). Conclusions The continuous observation of changes of serum β-HCG can be used as an important indicator of monitoring placental function in overdue pregnancy