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目的探讨家兔眼肌及视神经的磁共振三维成像效果及序列优选。方法对10只健康家兔眼眶应用三维各向同性序列行磁共振成像,序列分别为T_2加权三维双回波稳态进动序列(3D-DESS),T_2加权可变翻转角三维快速自旋回波序列(3D-SPACE),T_1加权三维容积内插式屏气检查序列(3D-VIBE)。总结分析家兔眼肌及视神经在3种三维序列上的成像效果,分析比较3种序列的图像信噪比(SNR)及对比度噪声比(CNR),并对所得图像的家兔眼肌和视神经的显示效果进行评分,选出家兔眼眶结构最佳的磁共振成像序列。结果 3D-DESS的眼肌、视神经SNR与其余两种序列比较,差异有统计学意义(P<0.05);3D-DESS的眼肌、视神经CNR与其余两种序列比较,除了3D-DESS与3D-SPACE的视神经CNR无明显差异(P>0.05),其余差异均有统计学意义(P<0.05);在显示眼肌及视神经效果方面3D-DESS显示的完整度、均匀度、轮廓清晰度显著优于3D-VIBE(P<0.05),除了眼肌完整度及轮廓清晰度以及视神经完整度方面3D-DESS没有显著优于3D-SPACE(P>0.05),其余评分均显著优于3DSPACE(P<0.05)。结论 3种3D成像序列相比较,3D-DESS具有良好的SNR及CNR,可以清楚地显示家兔眼肌和视神经的解剖与走行,可作为家兔眼眶和视神经成像的首选序列。
Objective To investigate the three-dimensional magnetic resonance imaging and sequence optimization of oculomotor and optic nerve in rabbits. Methods Three-dimensional isotropic magnetic resonance imaging was performed on the orbit of 10 healthy rabbits. The sequences were T-weighted 3D double-echo steady-state precession sequence (3D-DESS), T_2-weighted variable inversion angle 3D fast spin echo Sequence (3D-SPACE), T_1 weighted three-dimensional volume-interpolated breath-hold check sequence (3D-VIBE). The imaging results of three kinds of 3D sequences of the oculomotor muscles and optic nerves in rabbits were analyzed and compared. The SNR and contrast-to-noise ratio (CNR) of the three sequences were analyzed and compared. The results of the scoring, selected rabbit orbital structure of the best magnetic resonance imaging sequence. Results Compared with the other two sequences, the eye muscle and optic nerve SNR of 3D-DESS were significantly different (P <0.05). Compared with the other two sequences, There was no significant difference in CNR of -SPACE between the two groups (P> 0.05), and the differences were statistically significant (P <0.05). The 3D-DESS showed significant difference in the degree of integrality, 3D-DESS was significantly better than 3D-SPACE (P <0.05), except 3D-DESS for ocular muscle integrity and contour clarity and optic nerve integrity (P <0.05), and the remaining scores were significantly better than 3DSPACE (P <0.05). Conclusions 3D-DESS has good SNR and CNR compared with the three kinds of 3D imaging sequences. It can clearly show the anatomy and movement of oculomotor and optic nerve in rabbits and can be used as the first choice of orbit and optic nerve imaging in rabbits.