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目的探讨2015-2016年抗生素不合理应用情况及干预措施。方法随机选择医院2015年6月-2016年6月病历或处方1 200份,每月随机抽取50份门诊处方(A组)、25份手术病历(B组)、25份非手术病历(C组)。分析所选病历抗生素应用情况,并针对抗生素不合理应用情况提出相应的干预措施。结果 A组抗生素单用占72.88%高于B组的27.37%和C组的43.33%,B组两种抗生素联用占58.76%明显高于A组的23.73%和C组的47.04%,差异均有统计学意义(P<0.05)。1 200份病历与处方中不合理应用抗生素134份(11.17%)。干预后不合理率为35.82%(48/134)低于干预前的64.18%(86/134),差异有统计学意义(χ~2=21.552,P<0.05)。结论为增强抗生素的使用效果,减少耐药性发生,临床医师应严格遵循用药指征,规范应用抗生素,减少不合理应用现象,使抗生素发挥最大作用。
Objective To investigate the irrational use of antibiotics and interventions during 2015-2016. Methods A total of 1 200 medical records or prescriptions were randomly selected from June 2015 to June 2016 in the hospital. A total of 50 outpatient prescriptions (group A), 25 surgical records (group B) and 25 non-surgical medical records (group C) ). Analyze the application of selected medical records of antibiotics, and put forward corresponding interventions for the unreasonable application of antibiotics. Results The single use of antibiotics in group A accounted for 72.88% compared with 27.37% in group B and 43.33% in group C respectively. The combined use of two antibiotics in group B accounted for 58.76%, significantly higher than that in group A 23.73% and group C 47.04% There was statistical significance (P <0.05). 134 cases (11.17%) of unreasonable use of antibiotics in 1 200 medical records and prescriptions. The unreasonable rate after intervention was 35.82% (48/134), which was lower than 64.18% (86/134) before intervention, the difference was statistically significant (χ ~ 2 = 21.552, P <0.05). Conclusion To enhance the use of antibiotics and reduce the occurrence of drug resistance, clinicians should strictly follow the indications for drug use, regulate the use of antibiotics and reduce the phenomenon of unreasonable use, so that antibiotics play a maximum role.