糖尿病性水疱病是一种发病率较低的糖尿病皮肤合并症。因无自觉不适,往往不被患者注意,它可能是难治性溃疡或坏疽的前凑,应有足够的认识、我们观察的五例中大多数发生于病程长,血糖控制不良,合并有神经病变、微血管病变、视网膜病变、糖尿病肾病的患者。本文就糖尿病水疱发生的组织病理学、病因学及治疗学介绍了目前的看法。 Diabetic blister disease is a less common form of diabetic skin complication. Because there is no conscious discomfort, often not the patient’s attention, it may be refractory ulcer or gangrene before the minato, there should be adequate knowledge, we observed in most of the five cases occurred in the long course of the disease, poor blood glucose control, with nerve Lesions, microangiopathy, retinopathy, diabetic nephropathy. This article presents the current view on the histopathology, etiology and treatment of diabetic blisters.