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目的:检测O型孕妇血清ABO同种异体免疫型IG抗体效价。方法:将1204例O型孕早期孕妇按照其夫的血型分为四组,即O-A、O-B、O-AB-A、O-AB-B,用微柱凝胶法抗人球蛋白试验分别测定抗体效价;同时从中随机选择304例抗体效价≤1:64的孕妇定期检测。结果:在O-A、O-B组中及O-AB组中抗A及抗BIgG抗体效价>64的病例分别占29.88%,19.92%,20.00%及18.18%,各血型组合均有发生新生儿溶血病的可能性,差异无显著性(P>0.05);部分抗体效价低于1:64的孕妇在孕后期效价上升,与孕早期比较差别有统计学意义(t=2.271,P<0.05),且随孕周增大而上升(r=0.979,t=8..293,P<0.05)。结论:常规对孕妇血清血型抗体IgG效价进行检测有助于有助于诊断新生儿溶血病(hemolytic disease of the newborn,HDN),指导临床干预措施,尤其应该注重低抗体效价孕妇的定期检测。
Objective: To detect the serum ABO alloantibody IG antibody titer of O pregnant women. Methods: 1204 pregnant women with O-type pregnancy in early pregnancy were divided into four groups according to their husband’s blood type: OA, OB, O-AB-A and O-AB-B. Antibody titers; at the same time randomly selected from 304 cases of antibody titer ≤ 1: 64 pregnant women regular testing. Results: In OA, OB group and O-AB group, anti-A and anti-BIgG antibody titers> 64 accounted for 29.88%, 19.92%, 20.00% and 18.18%, respectively. (T = 2.271, P <0.05). There was no significant difference between the two groups (P> 0.05). The titer of some pregnant women with antibody titer less than 1:64 increased at the second trimester of pregnancy, , And increased with gestational age (r = 0.979, t = 8..293, P <0.05). CONCLUSIONS: Conventional detection of IgG titer of blood group antibody in pregnant women may help to diagnose hemolytic disease of the newborn (HDN), guide clinical intervention, and especially pay attention to the regular detection of pregnant women with low antibody titer .