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取三例一般型一级的软骨肉瘤及不同年令正常人股骨头关节软骨,经4mol/L盐酸胍提取和氯化铯平衡等密度梯度离心,分析蛋白多糖组份的化学组成,并用Sepharose CL-2B层析分析蛋白多糖分子大小。初步结果,两例软骨肉瘤蛋白多糖的化学组成和分子大小与新生儿接近,另一例软骨肉瘤蛋白多糖的化学组成和分子大小与成年人相似。此结果说明软骨肉瘤生物学行为的多变性及其蛋白多糖的异质性。
Take three cases of general grade chondrosarcoma and normal femoral head articular cartilage from different years, the chemical composition of proteoglycan components was analyzed by density gradient centrifugation with 4mol / L guanidine hydrochloride and cesium chloride balance, and the chemical composition of proteoglycan was analyzed by Sepharose CL -2B chromatographic analysis of proteoglycan molecular size. Preliminary results showed that the chemical composition and molecular size of two chondrosarcomas were similar to those of newborns. In another case, the chemical composition and molecular size of chondrosarcoma were similar to those of adults. This result demonstrates the variability of chondrosarcoma biological behavior and the heterogeneity of proteoglycans.