论文部分内容阅读
1977年自 Yamasak 等应用 Ames 试验成功检测吸烟者尿的致突变性后,许多作者曾进行了一系列接触不同环境遗传毒物人群尿的致突变性研究,并证实抽烟与肯定职业接触者尿的致突变活性增高。因此就此类危险性接触的人群而言,尿致突变性试验可以作为快速测定接触诱变物的方法。本研究目的是考验此方法对接触多种、未知诱变物人群在组织大规模筛检规划时的可行性。同时还
Since 1977, Yamasak et al. Have successfully tested the urine mutagenicity of smokers using the Ames test. Many authors conducted a series of studies on the mutagenicity of urine in people exposed to various environmental genotoxic agents and confirmed that smoking and certain occupational exposure to urinary Mutation activity increased. Therefore, for such risk-exposed populations, urine mutagenicity assays can be used as a rapid method of determining contact mutagens. The purpose of this study was to test the feasibility of this method for large-scale screening programs of exposure to multiple and unknown mutagens. Also at the same time