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目的探讨淮北矿区尘肺结核病人的耐药情况,为临床制定化疗方案及预防措施提供科学依据。方法对活动性尘肺结核病人按《全国结核病细菌学检验规程》的要求,用改良罗氏法进行痰结核杆菌培养,培养阳性菌株采用绝对浓度间接法进行6种抗结核药物的耐药性测试。结果尘肺结核病人的痰结核分枝杆菌培养阳性55例,耐药38例,总耐药率为69.1%。初始耐药率为33.3%,耐多药率为11.1%;获得性耐药率为86.5%,耐多药率为45.9%。抗结核药的耐药顺位为R、H、Z、S、P、E。结论尘肺结核病人耐药情况不容乐观,应加强对尘肺结核病人尤其是耐药结核病人临床治疗的管理,制定合理的化疗方案至关重要。
Objective To investigate the drug resistance of pneumoconiosis patients in Huaibei mining area and to provide a scientific basis for establishing the chemotherapy regimen and preventive measures. Methods According to the requirements of National Tuberculosis Bacteriological Test Regulation, active tuberculosis patients were cultured in sputum with Mycobacterium tuberculosis by modified Roche method. The positive strains were tested for resistance to six anti-tuberculosis drugs by the absolute concentration indirect method. Results 55 cases of sputum positive Mycobacterium tuberculosis were found in 38 cases of pneumoconiosis and 38 cases of drug resistance. The total drug resistance rate was 69.1%. The initial drug resistance rate was 33.3%, the multidrug resistance rate was 11.1%, the acquired drug resistance rate was 86.5% and the multidrug resistance rate was 45.9%. Resistance to anti-TB drug cis-position R, H, Z, S, P, E. Conclusion The resistance of patients with pneumoconiosis is not optimistic. The management of clinical treatment of patients with pneumoconiosis, especially drug-resistant TB, should be strengthened. It is very important to develop a rational chemotherapy regimen.