Coleman等报告18岁以下的Down’s综合征患者的甲状腺机能减退(甲减),16例中有15例患淋巴细胞性甲状腺炎,这一发现引起作者的兴趣。甲状腺自身免疫在Down’s综合征患者的甲状腺机能减退中所起的作用还未完全肯定。Mellon等曾发现,患Down’s综合征的年青人中普遍地存在抗甲状腺抗体,同时他对成年患者中的甲状腺机能减退也有所描述。因为自身免疫甲状腺炎的发生随年龄而增加。作者测定了42名(20名女性,22名男性)18岁以上的(18—64岁之间)Down’s综合征患者的抗甲状腺抗体。其中多数有常规的三体性21、几例有三体性21和正常细胞系嵌合。用被动红细胞凝集 Coleman et al. Reported the hypothyroidism (hypothyroidism) in patients with Down’s syndrome under 18 years of age and in 15 of 16 patients with lymphocytic thyroiditis, a finding of interest. The role of thyroid autoimmunity in hypothyroidism in patients with Down’s Syndrome has not yet been fully confirmed. Mellon et al. Have found that anti-thyroid antibodies are commonly present in young people with Down’s syndrome and that they also describe hypothyroidism in adult patients. Because the occurrence of autoimmune thyroiditis increases with age. The authors tested anti-thyroid antibodies in 42 patients (20 females, 22 males) older than 18 years of age (18-64 years) with Down’s Syndrome. Most of them have a conventional trisomy 21. Several cases have trisomy 21 and chimeric normal cell lines. With passive erythrocyte agglutination