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为探讨睾丸肿瘤组织ＨＬＡ－Ｉ抗原表达与预后的关系，采用免疫组织化学方法（ＡＢＣ法）对５５例睾丸肿瘤组织的石蜡切片进行检测，以观察其ＨＬＡ－Ｉ抗原的表达情况。结果：正常睾丸组织、间质组织Ｌｅｙｄｉｇ细胞呈深棕黄染色（卅），在曲细精管内Ｓｅｒｔｏｌｉ细胞染色（）。５５例睾丸肿瘤组织中，精原细胞瘤Ⅰ期的７２．０％，Ⅲ期的５４．６％染色；非精原细胞瘤仅Ⅰ期的７５．０％染色，ＨＬＡ－Ｉ抗原的表达随肿瘤临床分期增加而减弱或消失；ＨＬＡ－Ｉ抗原表达阳性的睾丸肿瘤的预后比表达阴性者好（Ｐ＜０．０５）。表明某些睾丸肿瘤ＨＬＡ－Ｉ抗原表达的减少与组织学类型、临床分期和肿瘤病理学特点有关。提示这些睾丸肿瘤能逃逸宿主的免疫监视，增加肿瘤的侵袭性；睾丸肿瘤组织中ＨＬＡ－Ｉ抗原表达可作为患者预后及监视治疗方案的有用指标。
To investigate the relationship between HLA-I antigen expression and prognosis in testicular tumor tissues, immunohistochemistry (ABC method) was used to detect the paraffin sections of 55 cases of testicular tumor tissues to observe the expression of HLA-I antigen. Results: The normal testis and interstitial Leydig cells were stained dark brown (卅), stained with Sertoli cells in the seminiferous tubules. 55 cases of testicular tumor tissue, seminoma 72.0% Ⅰ stage, Ⅲ phase 54.6% staining; non-seminoma only Ⅰ stage 75.0% staining, HLA-I antigen expression The clinical staging of tumor decreased or disappeared. The prognosis of testicular tumors with HLA-I antigen expression was better than those with negative expression (P <0.05). The reduction of HLA-I antigen expression in some testicular tumors was associated with histological type, clinical stage and tumor pathology. These testicular tumors can escape the immune surveillance of the host and increase the invasiveness of the tumor. The expression of HLA-I antigen in the testicular tumor tissue can be used as a useful indicator of prognosis and monitoring of the treatment.