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研究喉鳞癌中Ｃ－ｍｙｃ基因表达与预后的关系。方法应用免疫组织化学ＡＢＣ法检测６４例喉鳞癌、１０例喉乳头状瘤、６例喉正常粘膜组织中Ｃ－ｍｙｃ基因的表达。结果１．Ｃ－ｍｙｃ在上述３种组织中表达率分别为７０％、３０％、０％，差别有显著性（Ｐ＜０．０１）；２．Ｃ－ｍｙｃ表达与喉鳞癌ＴＮＭ分期、颈淋巴转移及５年生存期相关（Ｐ＜０．０５）。结论Ｃ－ｍｙｃ在喉上皮中的分布与其恶性程度相关，Ｃ－ｍｙｃ表达可作为喉鳞癌病情进展和预后不良的客观指标。
To study the relationship between C-myc gene expression and prognosis in laryngeal squamous cell carcinoma. Methods Immunohistochemistry ABC was used to detect the expression of C-myc gene in 64 cases of laryngeal squamous cell carcinoma, 10 cases of laryngeal papilloma and 6 cases of normal laryngeal mucosa. Results 1. The expression rates of C-myc in these three tissues were 70%, 30%, and 0%, respectively, with significant difference (P<0.01). C-myc expression was associated with TNM staging, cervical lymph node metastasis, and 5-year survival period (P<0.05). Conclusion The distribution of C-myc in the laryngeal epithelium is related to its malignancy. C-myc expression can be used as an objective indicator of progression and poor prognosis of laryngeal squamous cell carcinoma.