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上皮生长因子(EGF)是含53个氨基酸的多肽。用 EGF1mg 及液体石蜡4ml 与含或不含蛋白酶抑制剂的基质(白凡士林:纯羊毛脂为4:1)混合配成总量为20g 的软膏。蛋白酶抑制剂的终浓度:nafamostat 甲磺酸盐分别为0.03,0.3,3.0 mg/g,加贝酯甲磺酸盐为3.0,10.0,30.0 mg/g,明胶为1.0,5.0,25.0mg/g。将此软膏0.2 g/d 涂于大鼠背部开放性伤口创面(id 10mm),观察伤口内肉芽组织干重、糖醛酸及羟脯氨酸含量。结果给含蛋白酶抑制剂的 EGF 软膏后3天,肉芽组织干重均明显增加(p<0.05),而不含者则无此作
Epithelial growth factor (EGF) is a 53 amino acid polypeptide. A total of 20 g of ointment was made by mixing 1 mg of EGF and 4 ml of liquid paraffin with a matrix (white petrolatum: pure lanolin 4: 1) with or without protease inhibitors. Final concentrations of protease inhibitors: nafamostat mesylate 0.03, 0.3, 3.0 mg / g, gabexate mesylate 3.0, 10.0, 30.0 mg / g, gelatin 1.0, 5.0, 25.0 mg / g . The ointment 0.2 g / d was applied to open the back of the wound in rats (id 10mm), to observe the wound granulation tissue dry weight, uronic acid and hydroxyproline content. RESULTS: After 3 days of EGF ointment containing protease inhibitor, the dry weight of granulation tissue increased significantly (p <0.05), but not in the absence of EGF ointment