问题:在出生后的最初5年,减少房屋尘螨(HDM)变应原暴露并改变饮食中脂肪酸构成是否可以降低5岁时发生哮喘的风险? 方法设计:随机,2×2因子设计,安慰剂对照试验。分配:{隐藏~*}~+。盲法:对受试者(仅饮食干预)、结果判定者和实验室人员设盲。随访时间:5年。地点:澳大利亚悉尼6家医院的产前门诊。 Question: Is it possible to reduce the risk of developing asthma at the age of 5 by reducing exposure to house dust mite (HDM) allergens and changing fatty acid composition in the diet during the first 5 years of life? Design of Methods: Randomized, 2x2 factor design, comfort Agent control test. Assign: {hide ~ *} ~ +. Blindness: Subjects (dietary intervention only), blind decision makers and laboratory personnel. Follow-up time: 5 years. Location: Prenatal Clinic at 6 hospitals in Sydney, Australia.