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60年代用葡萄糖－胰岛素－钾（GIK）溶液治疗急性心肌梗塞（AMI）仅取得表面效果；1967年报告的840例多中心试验证明，GIK对AMI患者无益，以致对这种疗法的兴趣锐减。70年代的小样本试验说明GIK很有效；近来有报告证明，620例糖尿病伴AMI患者葡萄糖和胰岛素治疗能明显降低1年病
In the 1960s, treatment of acute myocardial infarction (AMI) with a glucose-insulin-potassium (GIK) solution achieved only surface effects; 840 multicenter trials reported in 1967 demonstrated that GIK was not beneficial to AMI patients and the interest in this therapy was diminished . A small sample of tests in the 1970s showed that GIK is very effective; recently, it has been reported that glucose and insulin therapy in 620 patients with diabetes mellitus and AMI can be significantly reduced by 1 year