利用系膜细胞培养技术,我们观察了IgA肾病(IgAN)患者血清对系膜细胞的影响,同时探讨了系膜细胞增殖与IgAN病理改变的关系。材料及方法:①经肾活检诊断IgAN患者,男性24例,女性14例,平均年龄28岁(16～52岁),肾功能均正常,均未用免疫抑制剂治疗。健康志愿者男性12例,女性7例,平均年龄31岁(18～45岁)。②人胎肾系膜细胞培养,取新鲜人胎肾皮质经80目, Using mesangial cell culture technique, we observed the effect of serum of patients with IgA nephropathy (IgAN) on mesangial cells, and explored the relationship between mesangial cell proliferation and pathological changes of IgAN. MATERIALS AND METHODS: ① IgAN patients were diagnosed by renal biopsy. There were 24 males and 14 females with an average age of 28 years (range, 16 to 52 years) and normal renal function. None were immunosuppressed. Healthy volunteers, 12 males and 7 females, mean age 31 years (18 to 45 years old). ② human fetal mesangial cell culture, fresh human fetal renal cortex by 80 mesh,