本文通过测定胎鼠肺中~3H乙酸钠掺入脂肪酸的程度,观察脂肪酸与肺表面活性物质脂质合成代谢之间的关系。结果发现新合成脂肪酸84％掺入磷脂中,经地塞米松刺激后,总脂质和磷脂部分分别增加40％与34％,而中性脂与糖脂部分无明显变化。从~3H乙酸钠掺入率、测磷含量和比放射活性的结果都显示,新合成脂肪酸是优先地参与肺表面活性物质特征性磷脂——饱和磷脂酰胆碱、磷脂酰甘油的合成,地塞米松对肺表面活性物质磷脂的合成有明显的促进作用。 In this paper, the determination of the degree of incorporation of fatty acids by ~ 3H sodium acetate in fetal rat lungs was performed to observe the relationship between fatty acids and the lipid metabolism of pulmonary surfactant. The results showed that 84% of the new synthetic fatty acids were incorporated into the phospholipids. After dexamethasone stimulation, the total lipids and phospholipids increased by 40% and 34%, respectively, while the neutral lipids and glycolipid did not change significantly. From ~ 3H sodium acetate incorporation rate, measured phosphorus content and specific radioactivity results show that the new synthetic fatty acids are preferentially involved in pulmonary surfactant characteristic phospholipids - saturated phosphatidylcholine, phosphatidyl glycerol synthesis, and Dexamethasone on pulmonary surfactant phospholipid synthesis has a significant role in promoting.